| Project Detail |
Light-induced 3D printing for degradable antimicrobial materials
Light-induced 3D printing (L3DP) is distinguished by its use of clean energy, high resolution, and precision, rendering it well-suited for applications in medical research, such as the exploration of antimicrobial materials. Supported by Marie Sklodowska-Curie Actions (MSCA), the PhotoAntiMic3DP project intends to leverage antimicrobial photodynamic therapy (aPDT), which exploits the interaction between a photo-sensitiser and light. This approach offers an alternative to antimicrobial materials that struggle to keep pace with the evolving resistance of microbes. Given the necessity for diverse combat strategies to address this challenge, the project will integrate zinc phthalocyanine as a photo-sensitiser into 3D materials to confer degradable photo-antimicrobial properties. This capability is enabled by dibenzazapine and triazolinedione, which undergo reversible reactions with light and buffer solutions.
It has been an ongoing requirement for humankind to access useful objects or to provide the missing part of damaged products. 3D printing (3DP) has become popular by completing these deficiencies in a very short time and low cost. Its many derivatives are available, however, it is a necessity to choose suitable modules and inks that fulfill the needs of in today’s world. Energy consumption of the world is increasing rapidly and this concept should be carefully considered in every step to be taken from social life to industrial life. Thus, light-induced 3D printing (L3DP) stands out with its features such as using clean energy source, high resolution and accuracy. Nonetheless, substantial effort is necessary to identify and put into action suitable photochemical interactions for this objective. Significantly, the selection of these interactions must be carried out carefully since the resulting materials should meet other contemporary demands; such as Recyclability. Dibenzazapine (DBA) and triazolinedione (TDA) are important molecules capable of giving light-induced reactions. Their reversible reactions with light and buffer solutions offer them the advantage to form degradable products and they can be promising candidates for L3DP. On the other hand, following the impact of COVID-19, the medical industry has reached a pivotal moment where the significance of antimicrobial materials has been better understood. However, the developed materials cannot keep up with the resistance rate of microbes and different combat strategies are necessity to cope with them. Antimicrobial photodynamic therapy (aPDT) is method which is utilized the interaction between photosensitizer (PS) and light, and it can be strong alternative for this purpose. In this context; zinc phthalocyanine as photosensitizier will be incorporated into 3D materials to obtain degradable photoantimicrobial properties thanks to DBA and TAD photochemical reactions. |
