| Project Detail |
The sensing of blood nutrient availability, storage, and delivery requires robust inter-tissue crosstalk mechanisms which, for the last 70 years, we have still trying to understand in health and disease. When these mechanisms fail, metabolic pathologies such as Metabolic Syndrome (MetSy) ensue. MetSy is a complex entity that has emerged as a worldwide epidemic. The lack of knowledge of its nature, the absence of any efficient treatment, and the increasing prevalence imply a major public health concern. MetSy is defined as abdominal obesity, insulin resistance, misbalance in lipid profile, and high cardiovascular and diabetes type 2 risks. These factors, dysregulated simultaneously, suggest an underlying mechanism linking all these metabolic impairments. In 2019, I published an article proposing a novel nutrient delivery mechanism from blood to tissues based on extracellular vesicles (EVs) biology. Since then, other groups have corroborated our findings, supporting the idea that, as a complementation of the classical nutrient delivery mechanisms, EVs in circulation (cEVs) are able to deliver metabolic fuels from blood to tissues. While this new cEVs-based mechanism is occurring in healthy subjects, we don´t know if it is falling in MetSy patients, or even if it is relevant enough to alter human physiopathology. METEV aims to study these last two concepts, to address a better understanding of metabolic pathologies, in particular, the role of cEVs in the development of MetSy. My main personal objective is to learn (training) and take advantage of cutting-edge technologies to improve the knowledge of metabolic pathologies with potential relevant implications in multiple fields of medicine. This will allow forging future interdisciplinary collaborations with professionals from different areas. The present MSCA enables the development of my own collaborative network, as I will work at the Hospital La Fe (Spain), with a secondment at Aalborg University Hospital (Denmark). |
