| Project Detail |
A simple and effective way to improve tumour cell targeting and therapy uptake
Getting drugs to cancerous tumours and ensuring their uptake and efficacy is a tremendous challenge. Existing drug delivery systems that encapsulate the therapies have limited targeting. Attaching small molecules (targeting ligands) to therapy nanocarriers can improve tumour binding affinity and cellular uptake. However, current procedures to do so have harsh preparation conditions, limited success and poor control over the ligand’s orientation, the latter impacting its efficacy in the body. Funded by the European Research Council, the OatLive project aims to develop an efficient yet simple and mild method to activate on-demand nanocarriers of the therapeutics. It could not only enable new targeted therapies but also reduce the systemic toxicity of existing ones. |
