| Project Detail |
Preventing type 2 diabetes: wearable technology with physics-informed machine learning
Impaired glucose tolerance, with or without impaired fasting glucose tolerance, is a manifestation of so-called prediabetes that can be reversed without the use of prescription drugs to prevent progression to type 2 diabetes (T2D). Building on patient-specific mathematical models developed within the EU-funded MISSION-T2D project, the Italian SME Spindox Labs will develop a prototype tool for the real-time prediction of prediabetic risk through the EU-funded PRAESIIDIUM project. The models simulate metabolism, pancreas hormone production, microbiome metabolites, the inflammatory process and immune system response. The novel prediction algorithm, based on physics-informed machine learning combining the model with real-life data, will be piloted harnessing wearable sensors. Success could prevent the development of T2D in hundreds of millions worldwide.
The incidence of undiagnosed diabetes accounts for 36% European adults, while 541M adults worldwide have Impaired Glucose Tolerance (IGT), an important risk factor for further T2D development. Both IGT and/or Impaired Fasting Glucose (IFG) are intermediate glucose mishandling (i.e. intermediate conditions in the healthy-T2D transition) and are manifestations of the so-called prediabetes condition. Prediabetes itself is not an extensively studied condition compared to the overt T2D, but it is also a condition that can be reversed without the prescription usage to not proceed into T2D. The aim of our project is to develop a prototype tool for the real-time prediction of the prediabetic risk based on a series of patient-specific mathematical models (firstly developed during the FP7 MISSION-T2D project) that simulate metabolism, pancreas hormone production, microbiome metabolites, inflammatory process and immune system response. The prediction algorithm will be based on a “physics-informed machine learning” approach. A rich dataset of real-life data will be combined with a mathematical model to overcome the limits of a “black-box” ML approach, while reducing the computational time for simulating the solutions of a heavy mathematical models and improving its prediction performances.We will collect the necessary training data (e.g. diet questionnaire, physical activity, blood metabolites and microbiome) from already existing clinical studies (used as retrospective trials) which are representative of the real-life scenarios of a prediabetes/diabetes risk insurgence in adulthood (20-80y): family history, Metabolic Syndrome, Liver disease and obesity. A newly dedicated multicentric pilot prospective observational study will be also performed, during which we will also equip the participants with wearable sensors (e.g. glucose monitoring, bioimpedance, heart rate, accelerometer). |
