Grants Notice For Limited Competition: Specific Pathogen Free Macaque Colonies To Support Hiv/Aids Research (U42 Clinical Trial Not Allowed The Purpose Of This Notice Of Funding Opportunity (Nofo) Is To Provide Continuing Support For Specific Pathogen-Free (Spf) Macaque Colonies Previously Funded Under The Auspices Of Par-21-089 And Par-18-669 That Support Human Immunodeficiency Virus (Hiv)/Acquired Immunodeficiency Syndrome (Aids) Research. Breeding Colonies Are Essential To Sustain Appropriate Spf Macaques For Research Related To Hiv/Aids. Pedigree Spf Macaques Are Free Of Certain Viruses, Which May Confound The Results Of Hiv/Aids-Related Investigations Or Present A Risk To The Personnel Who Care For The Animals. The Spf Macaques Are Genetically Characterized For Major Histocompatibility Complex (Mhc) Class I Types, Because Mhc Class I Genotypes Have Large Effects On Macaque Immune Responses To Simian Immunodeficiency Virus (Siv) That Can Induce Aids In Nonhuman Primates (Nhps) And On Human Immune Responses To Hiv
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