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Expression Of Interest Are Invited For Supply And Installation Of Spectrometers, Mass For Department Of Chemical Pathology In Prince Of Wales Hospital (Pwh), New Territories East Cluster (Ntec), Hospital Authority (Ha) M/D/O (Please Tick As Appropriate) 1.1.2 Validated Chromatographic Methods Such As Application Notes And Published Methods For The Separation Of Each Of The Following Analytes In Biological Samples. The Details Of Chromatographic Separation Shall Include But Not Be Limited To The Composition And Gradient Of The Mobile Phase Solutions, Flow Rate, Injection Volume, Total Run Time And Type And Temperature Of Analytical Column. (A) Plasma Amino Acids (B) Plasma Renin Activity (C) Plasma/Serum Aldosterone (D) Plasma Metanephrines (E) Serum/Plasma Estrogens (M) 1.1.3 Validated Data Acquisition Methods Such As Application Notes And Published Methods Of The Tandem Mass Spectrometer (Ms/Ms) For The Detection Of Each Of The Following Analytes In Biological Samples. The Details Of Mass Spectrometric Detection Shall Include But Not Be Limited To The Adjustable Parameters Of Ion Source And Data Acquisition. A Nitrogen Generation Complementary To The Proposed System Shall Be Provided. (A) Plasma Amino Acids (B) Plasma Renin Activity (C) Plasma/Serum Aldosterone Levels (D) Plasma Metanephrines (E) Serum/Plasma Estrogens (M) 1.1.4 A Data Processing Software For Analysing The Acquired Mass Spectrometry (Ms) Data. (M) 1.1.5 Connectivity To Laboratory Information System (Lis). This Shall Include But Not Be Limited To The Hardware And Software And Their Customization To Fulfil The Requirements Of Lis At Appendix I And Pwh. (M) 1.1.6 If Applicable, Tenderers Shall Provide A Reliable Anti-Virus, Anti-Spyware And Anti-Hacking Solution For The Medical Equipment/System On Offer. The Solution Provided Shall Not Affect The Normal Performance Of The Equipment/System. Details Of The Solution Shall Be Stated. Tenderers Shall Regularly Update The Anti-Virus Program. Preferably Using Hospitals Virus Definition, That Is, To Connect To Hospital Network For The Daily Update Of Anti-Virus Program. The Successful Tenderer Is Required To Follow The Latest Ha Network Security Policies And Guidelines. (M) 9 Eoi Ref.: Ntec/P&Mm/T5b/Cbv2324-T003 Eoi Clause Description Type Of Clause Yes No (Provide Details) M/D/O (Please Tick As Appropriate) 1.1.7 Provide Uninterrupted Power Supply Devices (Ups) To All Components Specified In This Tender Specifications Whenever Appropriate. The Ups Shall Be Maintenance-Free And Sealed Type And Equipped With Environmental Friendly Batteries, To Maintain Operation For At Least 15 Minutes During Power Failure. (M) 1.2 The Tenderer Shall Provide Brand New Equipment And All The Related Software. (M) 1.3 Provide All Reagents, Quality Controls, Calibrators And Consumables As Well As Manpower Of Qualifying Personnel For The Functional And Acceptance Testing Of The Equipment In This Tender Specifications. Pwh Reserves Final Right To Design And Decide The Scope Of Evaluation And Its Criteria Of Acceptance In Concordance With International Standards, E.G. Clinical Laboratory Standard Institute (Clsi) And LaboratoryS Accrediting Bodies, E.G. National Association Of Testing Authorities, Australia And/Or Hong Kong Laboratory Accreditation Scheme (Hoklas). (M) 1.4 The System Shall Occupy Space As Designated By Pwh. The Tenderer Are Required To Perform A Pre-Tender Site Visit To Study And Confirm Space And Associated Facilities For The Proposed System And Shall Confirm In Writing That The Conditions Of The Installation Site Are Suitable For Equipment Installation In Their Tender Submission. The Proposed System Required More Physical Space Shall Not Be Considered. (M) 10 Eoi Ref.: Ntec/P&Mm/T5b/Cbv2324-T003 Eoi Clause Description Type Of Clause Yes No (Provide Details) M/D/O (Please Tick As Appropriate) 1.5 Site Renovation/ Modification The Tenderer Shall Carefully Study And Confirm The Existing Facilities And Infrastructure In The Designated Area Of Pwh Including But Not Limited To Gas Exhaust, Electricity Supply, Water Supply And Concealed Or Under Floor Ducting Being Adequate And Suitable For The Proposed System. If Site Renovation/ Modification Is Required For The Accommodation, Installation And Implementation Of The Proposed System, The Tenderer Shall Provide Design, Plan And Details In The Tender Submission. The TendererS Site Modification Work Requirements Should Be Clearly Depicted In Appropriate Drawings, Which Should Be Accompanied By Detailed Information With Cross-Reference, Where Applicable, To The Drawings. The Site Renovation/ Modification Work Details Shall Include But Not Be Limited To The Dimensions, Layout, Openings And Other Relevant Information Regarding Concealed Or Under-Floor Ducting For Electrical Cables And Other Services. The Design, Plan And Details Of The Site Renovation/ Modification Shall Be Vetted And Approved Prior To The Award Of The Contract And The Quality Shall Be Evaluated And Accepted After The Completion Of Site Renovation/ Modification By The Electrical And Mechanical Services Department (Emsd) And Pwh. In Addition, The Tenderer Shall Ensure The Site Renovation/ Modification Is Conducted By Quality Constructor And Its Quality And Standard Shall Fulfil The Requirements Stipulated In Clause 3. Any Site Renovation/ Modification Related To The Proposed System Shall Be At No Cost. (M) 1.6 The Proposed System Shall Be Ready For Live Run With Compliance To All Requirements Of Stated In This Tender Specifications Within 6 Months From The Date Of Tender Award. (M) 1.7 The Tenderer Shall Provide Application Specialist Support For The Method Development For At Least 5 Years. The Methods To Be Developed Shall Include But Not Limited To Plasma Amino Acid, Plasma Renin Activity, Plasma/Serum Aldosterone, Plasma/Serum Estrogens, Etc. (M) 1.8 Except For The Parameters Of Sample Preparation, All Other Parameters Of The Application Methods Shall Be Directly Loaded Into The Control Software And Data Processing Unit Depicted In Clause 2.2.4 Without Manual Data Entry. (M) 1.9 The Tenderer Shall Provide All The Currently Available Methods And Continuously Update The Method Database For Every Newly Developed And Validated Method Throughout The Serviceable Life Of The System. (M) Section Ii - Technical Specifications 11 Eoi Ref.: Ntec/P&Mm/T5b/Cbv2324-T003 Eoi Clause Description Type Of Clause Yes No (Provide Details) M/D/O (Please Tick As Appropriate) 2.1 Ultra Performance Liquid Chromatography Unit 2.1.1 Liquid Chromatography Temperature Controlled Solvent Delivery Module 2.1.1.1 The Module Shall Use Binary Solvent Delivery Design. It Shall Be Able To Accommodate Four Different Solvents In Two Solvent Channels. The User Shall Be Able To Choose In Each Solvent Channel Between Two Different Solvents. (M) 2.1.1.2 The Module Shall Use Single Or Dual Pressure Transducers Or Functionally Equivalent Design For Module Performance Monitoring. (M) 2.1.1.3 The Module Shall Have Automatic And Continuous Compressibility Compensation To Ensure Stable Solvent Delivery. Functionally Equivalent Design Is Also Acceptable. (M) 2.1.1.4 The Module Shall Have The Capability For Direct Or Indirect Bubble Detection. (M) 2.1.1.5 The Module Shall Have The Capability For Automatic Or Manual Priming Of Module Fluidic Path. (M) 2.1.1.6 The Module Shall Have A Vacuum Degassing System With At Least Six Chambers And Separate Channels For Each Mobile Solution And Wash Solvents. (M) 2.1.1.7 The Module Shall Be Equipped With Controllable Valves Or Equivalent Design To Deliver Fast Module Priming And Start-Up Times. (M) 2.1.1.8 Flow Rate Shall Be Ranged From 10 L/Min To 2 Ml/Min Or Wider Range, In 1 L/Min Increments Or Finer. (M) 2.1.1.9 Flow Precision Shall Be ±0.1% Relative Standard Deviation (Rsd) And Flow Accuracy Shall Be ±1% Or Better. (M) 2.1.1.10 Maximum Operating Pressure Shall Not Be Less Than 18,000Psi At A Flow Rate Of 1 Ml/Min. (M) 2.1.1.11 The Module Shall Be Able To Run High Performance Liquid Chromatography (Hplc) Columns With Particle Sizes Ranged From Sub-2 M To 7.0 M Or Wider Range, At Flow Rates Above 0.5 Ml/Min Without Any Hardware Modifications. (M) 2.1.1.12 The Module Shall Automatically Condition And Blend Up To 2 Solvents For Isocratic Or Gradient Operation With Composition Accuracy Of ± 0.5% And Composition Precision Of ± 0.2% (Relative Sd Based On Retention Time). (M) 2.1.1.13 Total System Dwell Volume Shall Be Less Than 110 l. (M) 12 Eoi Ref.: Ntec/P&Mm/T5b/Cbv2324-T003 Eoi Clause Description Type Of Clause Yes No (Provide Details) M/D/O (Please Tick As Appropriate) 2.1.2 Liquid Chromatography - Automated Sample Management Module 2.1.2.1 The Module Shall Have Random Access Capability To Any Sample Vial For Multi-Method Operation. (M) 2.1.2.2 The Module Shall Accommodate Sample Containers On Plate And Rack Formats: 96- Or 384-Well Microtiter Plate, 2 Or 4 Ml Vials On Rack Or Equivalent. (M) 2.1.2.3 The Module Shall Be Able To Simultaneously Accommodate At Least 2 Plates Or 2 Racks For The Above Sample Containers. (M) 2.1.2.4 The Module Shall Have Capability To Detect The Presence Of Sample Containers Before Injection. (M) 2.1.2.5 The Module Shall Have The Capability For Washing The Sampling Needle With At Least 2 Different Continuous Fresh Solvents From Independent Solvent Reservoirs. (M) 2.1.2.6 Sample Carryover Shall Be <0.003%. (M) 2.1.2.7 Typical Sample Volume Delivery Precision Shall Be < 0.3% Rsd. (M) 2.1.2.8 Injection Volume Shall Be Ranged From 1L To 1000 L Or Wider Range, With An Extended Injection Volume Option. (M) 2.1.2.9 The Temperature Of The Sample Compartment Shall Be Maintained From 4 To 40 ºc Or Wider Range, Programmable In 1 ºc Tender Link :
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