Mass Spectrometer – Lc-Ms System. The Most Important Parameters That Should Be Determined On The Lc-Hrms Device During The In-Process Control And For The Release Of The Manufactured Active Ingredients And Test Preparations (Investigational Medicinal Products (Imps) - Drugs For Clinical Studies) Are The Clear Determination Of The Identity Using The Exact Mass And Isotope Distribution, Confirmation Of The Peptide Sequence By Ms/Ms Experiments, Detection, Identification And Quantification Of Partly Isobaric By-Products, As Well As The Determination Of The Content Of The Target Peptides. Due To The Large Number Of Potential Analytes In The Intermediate And Final Products, With Possibly Very Fast Elution (Uhplc), The Speed Of The Device Combined With High Resolution Is Crucial. Quadrupole/Time-Of-Flight (Qtof) Devices Combine Both Aspects And Therefore Represent The Most Suitable Mass Detector For Our Purposes.
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